HCID 18918877, compound → HCID 18918968, compound

Participants

Reaction Steps

In 20% aqeuous acetic acid (10 ml) was dissolved ethyl 1-[4-(4-chlorobenzoyl)benzyl]-4-(diethoxymethyl)-imidazole-5-carboxylate (1.20 g) and the mixture was stirred at room temperature for 8 hours. This reaction mixture was diluted with water and extracted with ethyl acetate. The extract was washed serially with water, saturated aqueous NaHCO3 solution, and water, and dried over anhydrous magnesium sulfate. The solvent was then distilled off under reduced pressure and the residue was purified by silica gel column chromatography (developer; n-hexane: ethyl acetate=1:1) to provide the title compound as white powder (671 mg; yield 67%). 1H-NMR (CDCl3) δ: 1.38(3H,t,J=7.OHz), 4.41(2H,q,J=7.OHz), 5.66(2H,s), 7.26(2H,d,J=8.8Hz), 7.46(2H,d,J=8.8Hz), 7.70-7.79(5H,m), 10.42(1H,s).

Provenance & Evidence