反应详情

温度

80 °C

In toluene was dissolved 2-t-butyl-5-dimethylamino-4-(1-hydroxy)ethyl-3(2H)-pyridazinone (3.4 g) followed by addition of active manganese dioxide (17.0 g), and the mixture was stirred at 80° C. for 24 hours. The oxidizing agent was filtered off and the filtrate was concentrated. The residue was washed with n-hexane and diethyl ether and dried. Yellow powder, 2.5 g. 1 H-NMR (CDCl3) δ: 1.62(9H,s), 2.63(3H,s), 2.92(6H,s), 7.62(1H,s).

1. filtrationThe oxidizing agent was filtered off
2. concentrationthe filtrate was concentrated
3. washThe residue was washed with n-hexane and diethyl ether
4. customdried