HCID 18919314, compound → HCID 18919343, compound

HRID 1291226Notes

Reaction equation

HRID 1291226 reaction equation
[C:1]([N:5]1[C:10](=[O:11])[C:9]([CH:12]([OH:14])[CH3:13])=[C:8]([N:15]([CH3:17])[CH3:16])[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2]>C1(C)C=CC=CC=1.[O-2].[O-2].[Mn+4]>[C:12]([C:9]1[C:10](=[O:11])[N:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[N:6]=[CH:7][C:8]=1[N:15]([CH3:16])[CH3:17])(=[O:14])[CH3:13]

Participants

4

Reactant 1

HCID 18919314HCID 18919314, compound

Product 1

HCID 18919343HCID 18919343, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 1140TolueneSolvent

Conditions

Temperature
80 °C

Procedure

In toluene was dissolved 2-t-butyl-5-dimethylamino-4-(1-hydroxy)ethyl-3(2H)-pyridazinone (3.4 g) followed by addition of active manganese dioxide (17.0 g), and the mixture was stirred at 80° C. for 24 hours. The oxidizing agent was filtered off and the filtrate was concentrated. The residue was washed with n-hexane and diethyl ether and dried. Yellow powder, 2.5 g. 1 H-NMR (CDCl3) δ: 1.62(9H,s), 2.63(3H,s), 2.92(6H,s), 7.62(1H,s).

Workup

  1. filtrationThe oxidizing agent was filtered off
  2. concentrationthe filtrate was concentrated
  3. washThe residue was washed with n-hexane and diethyl ether
  4. customdried

Sources & evidence

ORD record
ord-8388e23933b64440b095da79a667760d
Source dataset
uspto-grants-1998_05
Patent number
US05753664

Reaction notes

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