Potassium Carbonate → 3-propyl-7H-pyrrolo[2,3-d]pyrimidin-4-one

참여 물질

반응 조건

반응 단계

Under argon gas, 7H-pyrrolo[2,3-d]pyrimidin-4(3H)-one (1.0 g) was dissolved in DMF (35 ml) with warming. Then, anhydrous potassium carbonate (1.02 g) and propyl iodide (1.08 ml) were added and the mixture was stirred at 55° C. for 20 hours. The insoluble matter was filtered off and the solvent was distilled off under reduced pressure. The residue was purified by flash column chromatography (silica gel; hexane: ethyl acetate=4:1-1:1) to provide the title compound (521 mg). 1H-NMR (CDCl3) 8: 0.96(3H,t,J=7.4Hz), 1.73-1.92(2H,m), 4.01(2H,t,J=7.4Hz), 6.71(1H,dd,J=2.2&3.4Hz), 7.01(1H,dd,J=2.2&3.4Hz), 7.94(1H,s).

출처 및 근거