Theobromine → HCID 18918943, compound

Participants

Reaction Steps

To a mixture of theobromine (0.90 g) and DMF (20 ml) was added sodium hydride (240 ml) as well as 4-(4-chlorobenzoyl)benzyl bromide (1.55 g) and the mixture was stirred at room temperature for 18 hours. This reaction mixture was diluted with water and extracted with ethyl acetate. The extract was washed with saturated aqueous NaCl solution and dried over anhydrous sodium sulfate. The solvent was then distilled off and the residue was washed with ether to provide the title compound as colorless powder (1.37 g, 67%). 1H-NMR (CDCl3) δ: 3.60(3H,s), 4.00(3H,s), 5.27(2H,s), 7.38-7.79(8H,m)

Provenance & Evidence