4-(4-isopropylphenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one → 2-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-(4-isopropylphenyl)-3(2H,4H)-1,2,4-triazolone

Participants

Reaction Steps

In the same manner as in Reference Example 5, starting from 1.72 g of (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol and 1.68 g of 4-(4-isopropylphenyl)-3(2H,4H)-1,2,4-triazolone, an about 1:1 mixture (0.89 g) of 2-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]- 4-(4-isopropylphenyl)-3 (2H, 4H)-1,2,4-triazolone and (1R)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol was obtained.

Provenance & Evidence