反应详情

In methanol (65.7 ml) was suspended 2-mercapto-7H-pyrrolo [2,3-d]pyrimidin-4(3H)-one (2.51 g) followed by addition of 1N-sodium hydroxide (15.75 ml) for dissolution. Then, a solution of 4-(4-fluorobenzoyl)benzyl bromide (5.06 g) in DME (15 ml) was added dropwise with ice-cooling. Then, the mixture was stirred at room temperature overnight. The solvent was then distilled off under reduced pressure and the residue was purified by flash column chromatography (silica gel; ethyl acetate: hexane=1:4-1:1-ethyl acetate) to provide the title compound (2.43 g).

1. temperaturecooling
2. distillationThe solvent was then distilled off under reduced pressure
3. customthe residue was purified by flash column chromatography (silica gel; ethyl acetate: hexane=1:4-1:1-ethyl acetate)