Potassium Carbonate → HCID 69960194, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-methyl-2-hydroxy-5H-thiazolo [3,2-a]pyrimidin-5-one (365 mg) and potassium carbonate (526 mg) in DMF (10 ml) was added 4-(4-chlorobenzoyl)benzyl bromide (664 mg) and the mixture was stirred at 80° C. for 2 hours. This reaction mixture was concentrated and the residue was diluted with water-ethyl acetate and extracted with ethyl acetate. The extract was purified by silica gel column chromatography (hexane: ethyl acetate: chloroform=2:1:1) and recrystallized from ethyl acetate to provide the title compound as colorless solid (400 mg).

Provenance & Evidence