Sodium hydride → HCID 18919046, compound

Participants

Reaction Steps

To a solution of 4-(4-chlorobenzoyl)benzyl alcohol (1.0 g) in DMF (20 ml) was added 60% sodium hydride (210 mg) and the mixture was stirred at room temperature for 10 minutes. Then, 2-chloro-3,5-dimethyl-4(3H)-quinazolinone (850 mg) was added and the mixture was stirred at room temperature for 1 hour and at 80° C. for 10 minutes. This reaction mixture was concentrated and the residue was dissolved in ethyl acetate, washed with water, dried, and concentrated. The residue was purified by silica gel column chromatography (hexane: ethyl acetate: chloroform=4:1:1) to provide the title compound as colorless solid (350 mg).

Provenance & Evidence