Sodium hydride → HCID 18919023, compound

Participants

Reaction Steps

To a solution of 4-(4-fluorobenzoyl)benzyl alcohol (1.0 g) in DMF (20 ml) was added 60% sodium hydride (210 mg) and the mixture was stirred at room temperature for 10 minutes. Then, 2-chloro-3,5-dimethyl-4(3H)-quinazolinone (907 mg) was added and the mixture was stirred at room temperature for 1 hour. This reaction mixture was concentrated and the residue was dissolved in ethyl acetate, washed with water, dried, and concentrated. The residue was purified by silica gel column chromatography (hexane: ethyl acetate =3:1) to provide the title compound as colorless solid (560 mg).

Provenance & Evidence