(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol → HCID 15285761, compound

HRID 129133Notes

Reaction equation

HRID 129133 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@@H:12](O)[CH3:13])[CH2:11][O:10]1.[N:15]1[CH:20]=[CH:19][C:18]([N:21]2[CH:25]=[N:24][NH:23][C:22]2=[O:26])=[CH:17][CH:16]=1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([O:10][CH2:11]1)[C@H:12]([N:23]1[C:22](=[O:26])[N:21]([C:18]2[CH:19]=[CH:20][N:15]=[CH:16][CH:17]=2)[CH:25]=[N:24]1)[CH3:13]

Participants

3

Reactant 2

HCID 10631861(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanolHCID 19373711155431-59-7

Product 1

HCID 15285761HCID 15285761, compoundYield 33.8%

Procedure

In the same manner as in Reference Example 5, starting from 1.42 g of (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol and 0.92 g of 4-(4-pyridyl)-3(2H,4H)-1,2,4-triazolone, 2-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-(4-pyridyl)-3(2H,4H)-1,2,4-triazolone (0.66 g) was obtained as colorless prisms.

Sources & evidence

ORD record
ord-33ab53e12bf848a98876b9cff3c96ba2
Source dataset
uspto-grants-1995_11
Patent number
US05466820

Reaction notes

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