Theophylline → HCID 18918941, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4,4'-bis(bromomethyl)benzophenone (1.75 g), theophylline (900 mg) and potassium carbonate (828 mg) in DMF (40 ml) was stirred at 40° C. for 1 hour. Then, 3,5-dimethyl-2-mercapto-4(3H)-quinazolinone (1.03 g) was added and the mixture was stirred at 60° C. for 1 hour. This reaction mixture was concentrated, the residue was dissolved in ethyl acetate, and the solution was washed with water, dried, and concentrated. The residue was purified by silica gel column chromatography (ethyl acetate) to provide the title compound as colorless solid (787 mg).

Provenance & Evidence