(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol → HCID 15285765, compound

HRID 129135Notes

Reaction equation

HRID 129135 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@@H:12](O)[CH3:13])[CH2:11][O:10]1.[F:15][C:16]([F:25])([F:24])[CH2:17][N:18]1[CH:22]=[N:21][NH:20][C:19]1=[O:23]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([O:10][CH2:11]1)[C@H:12]([N:20]1[C:19](=[O:23])[N:18]([CH2:17][C:16]([F:15])([F:25])[F:24])[CH:22]=[N:21]1)[CH3:13]

Participants

3

Reactant 2

HCID 10631861(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanolHCID 19373656HCID 19373656, compound

Product 1

HCID 15285765HCID 15285765, compoundYield 65.7%

Procedure

In the same manner as in Reference Example 5, starting from 1.36 g of (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol and 0.91 g of 4-(2,2,2-trifluoroethyl)-3(2H,4H)-1,2,4-triazolone, 2-[(1R,2S)-2-(2,4-difluorophenyl)2,3-epoxy-1-methylpropyl]-4-(2,2,2-trifluoroethyl)-3(2H,4H)-1,2,4-triazolone (1.25 g) was obtained as a colorless oil.

Sources & evidence

ORD record
ord-dcb6f692b3a64ab9a036a0ba90496599
Source dataset
uspto-grants-1995_11
Patent number
US05466820

Reaction notes

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