1,4'-Bipiperidine → HCID 18918847, compound

HRID 1291358Notes

Reaction equation

HRID 1291358 reaction equation
Cl[C:2]1[CH:29]=[CH:28][C:5]([C:6]([C:8]2[CH:27]=[CH:26][C:11]([CH2:12][O:13][C:14]3[N:15]=[C:16]4[CH:25]=[CH:24][CH:23]=[CH:22][N:17]4[C:18](=[O:21])[C:19]=3[CH3:20])=[CH:10][CH:9]=2)=[O:7])=[CH:4][N:3]=1.[N:30]1([CH:36]2[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]2)[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1>N1C=CC=CC=1>[CH3:20][C:19]1[C:18](=[O:21])[N:17]2[CH:22]=[CH:23][CH:24]=[CH:25][C:16]2=[N:15][C:14]=1[O:13][CH2:12][C:11]1[CH:26]=[CH:27][C:8]([C:6](=[O:7])[C:5]2[CH:28]=[CH:29][C:2]([N:39]3[CH2:40][CH2:41][CH:36]([N:30]4[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]4)[CH2:37][CH2:38]3)=[N:3][CH:4]=2)=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 786071,4'-BipiperidineHCID 189192902-[4-(6-Chloronicotinoyl)benzyloxy]-3-methylpyrido[1,2-a]pyrimidin-4-one

Product 1

HCID 18918847HCID 18918847, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 2-[4-(6-chloronicotinoyl)benzyloxy]-3-methylpyrido[1,2-a]pyrimidin-4-one (0.49 g, 1.21 mmol) and 4-piperidinopiperidine (0.402 g, 2.39 mmol) in pyridine (15 ml) was stirred at 90° C. overnight. The solvent was then distilled off under reduced pressure and the residue was purified by silica gel column chromatography (isopropyl ether: methylene chloride: methanol: ammonia=5:5:1:0.1) to provide a light-yellow oil.

Workup

  1. distillationThe solvent was then distilled off under reduced pressure
  2. customthe residue was purified by silica gel column chromatography (isopropyl ether: methylene chloride: methanol: ammonia=5:5:1:0.1)
  3. customto provide a light-yellow oil

Sources & evidence

ORD record
ord-4ce3dcc30ffc4c5590bfe444be99ff08
Source dataset
uspto-grants-1998_05
Patent number
US05753664

Reaction notes

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