Diethyl Pyrocarbonate → HCID 18919289, compound

Participants

Reaction Steps

To a solution of 2-[4-(4-carboxybenzoyl)benzyl]thio-3,5-dimethyl-4(3H)-quinazolinone (1.00 g, 2.26 mmol) in DMF (10.0 ml) was added DEPC (0.755 g, 4.63 mmol) and the mixture was stirred at room temperature for 10 minutes. Then, 4-hydroxypiperidine (0.522 g, 5.16 mmol) was added and the mixture was stirred at room temperature for 4 hours. The solvent was then distilled off and the residue was dissolved in ethyl acetate and washed with saturated aqueous NaCl solution. The organic layer was dried over MgSO4 and then concentrated under reduced pressure, and the residue was recrystallized from THF to provide colorless needles.

Provenance & Evidence