Potassium Carbonate → HCID 18919347, compound

Participants

Reaction Conditions

Reaction Steps

2-[4-(4-Hydroxybenzoyl)benzylthio]-3,5-dimethyl-4(3H)-quinazolinone (306 mg), 2-dimethylaminoethyl chloride hydrochloride (218 mg), and potassium carbonate (316 mg) were dissolved in DMF (5 ml) and the solution was stirred at 80° C. for 20 hours. This reaction mixture was concentrated and the residue was dissolved in ethyl acetate, washed with water, and dried. Then, hydrogen chloride/ethyl acetate was added and the precipitated hydrochloride was collected by filtration to provide the title compound as colorless solid (193 mg).

Provenance & Evidence