反应详情

A solution of 3,5-dimethyl-2-mercapto-4(3H)-quinazolinone (917 mg), 4-(4-acetoxybenzoyl)benzyl bromide (1.785 g) and 1N-aqueous sodium hydroxide solution (4.5 ml) in methanol (20 ml) was stirred at room temperature for 4 hours. This reaction mixture was concentrated and extracted with chloroform and the extract was washed with water, dried, and concentrated. The residue was purified by silica gel column chromatography (hexane: ethyl acetate=6:1) to provide the title compound as colorless solid (4.26 mg).

1. concentrationThis reaction mixture was concentrated
2. extractionextracted with chloroform
3. washthe extract was washed with water
4. customdried
5. concentrationconcentrated
6. customThe residue was purified by silica gel column chromatography (hexane: ethyl acetate=6:1)