Potassium Carbonate → HCID 18919066, compound

Participants

Reaction Steps

A solution of 2-[4-(4-hydroxybenzoyl)benzylthio]-3,5-dimethyl-4(3H)-quinazolinone (399 mg), 1-(2-chloroethyl)piperidine hydrochloride (185 mg) and potassium carbonate (392 mg) in DMF (5 ml) was stirred at 60° C. for 62 hours. This reaction mixture was concentrated and the residue was dissolved in ethyl acetate, washed with water, and dried. Then, hydrogen chloride/ethyl acetate was added and the precipitated hydrochloride was recovered by filtration to provide the title compound as colorless solid (368 mg).

Provenance & Evidence