Potassium Carbonate → HCID 18919138, compound

Participants

Reaction Steps

A solution of 2-[4-(4-hydroxybenzoyl)benzylthio]-3,5-dimethyl-4(3H)-quinazolinone (311 mg), 3-dimethylaminopropyl chloride hydrochloride (249 mg) and potassium carbonate (322 mg) in DMF (5 ml) was stirred at 60° C. for 18 hours. This reaction mixture was concentrated and the residue was dissolved in ethyl acetate, washed with water, and dried. Then, hydrogen chloride/ethyl acetate was added and the precipitated hydrochloride was collected by filtration to provide the title compound as colorless solid (185 mg).

Provenance & Evidence