Sodium Hydroxide → 2-[4-[4-(2-Acetoxyethoxy)benzoyl]benzylthio]-3,5-dimethyl-4(3H)-quinazolinone

Participants

Reaction Steps

A solution of 3,5-dimethyl-2-mercapto-4(3H)-quinazolinone (1.888 g), 4-(4-acetoxyethoxybenzoyl)benzyl bromide (3.895 g) and 1N-aqueous sodium hydroxide solution (14.3 ml) in methanol (30 ml) was stirred at room temperature for 30 minutes. This reaction mixture was concentrated and extracted with chloroform. The extract was washed with water, dried, and concentrated, and the residue was recrystallized from ethyl acetate to provide the title compound as colorless solid (2.597 g).

Provenance & Evidence