Dichloromethane → 3,5-dimethyl-2-[4-[4-(2-hydroxyethoxy)benzoyl]benzylthio]-4(3H)-quinazolinone

Participants

Reaction Steps

A solution of 2-[4-[4-(2-acetoxyethoxy)benzoyl]-benzylthio]-3,5-dimethyl-4(3H)-quinazolinone (1.75 g) and 1N-aqueous sodium hydroxide solution (15 ml) in methanol (50 ml)-dichloromethane (25 ml) was stirred at room temperature for 3 hours. This reaction mixture was extracted with dichloromethane and the extract was dried and concentrated. The residue was recrystallized from ethyl acetate to provide the title compound as colorless solid (1.278 g).

Provenance & Evidence