Dimethylcarbamoyl Chloride → 3,5-Dimethyl-2-[4-[4-(N,N-dimethylcarbamoyloxy)-benzoyl]benzylthio]-4(3H)-quinazolinone

Participants

Reaction Steps

A solution of 2-[4-(4-hydroxybenzoyl)benzylthio]-3,5-dimethyl-4(3H)-quinazolinone (478 mg), dimethylcarbamoyl chloride (0.15 ml) and potassium carbonate (315 mg) in DMF (7 ml) was stirred at 50° C. for 48 hours. This reaction mixture was concentrated and the residue was dissolved in ethyl acetate. The solution was washed with water, dried, and concentrated. The residue was recrystallized from ethyl acetate to provide the title compound as colorless solid (346 mg).

Provenance & Evidence