1-Methylpiperazine → 3,5-Dimethyl-2-[4-[4-[2-(4-methylpiperazinyl)ethoxy]benzoyl]benzylthio]-4(3H)-quinazolinone dihydrochloride

Participants

Reaction Steps

A solution of 2-[4-[4-(2-chloroethoxy]benzoyl]benzylthio]-3,5-dimethyl-4(3H)-quinazolinone (173 mg) and 1-methylpiperazine (0.12 ml) in DMF (5 ml) was stirred at 100° C. for 15 hours. This reaction mixture was concentrated and the residue was dissolved in ethyl acetate, washed with water, and dried. Then, hydrogen chloride/ethyl acetate was added and the precipitated hydrochloride was collected by filtration and dried to provide the title compound as colorless solid (122 mg).

Provenance & Evidence