HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 18919198, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(1,1'-Biphenyl)-4-yl-2-bromoethanone | HCID 67282 | — |
| Reactant | 2-[4-(4-hydroxybenzoyl)benzylthio]-3,5-dimethyl-4(3H)-quinazolinone | HCID 18918888 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 18919198 | HCID 18919198 | 37.2% |
Reaction Steps
A solution of 2-[4-(4-hydroxybenzoyl)benzylthio]-3,5-dimethyl-4(3H)-quinazolinone (398 mg), 4-phenylphenacyl bromide (290 mg) and potassium carbonate (440 mg) in DMF (7 ml) was stirred at room temperature for 72 hours. This reaction mixture was concentrated and the residue was purified by silica gel column chromatography (dichloromethane: ether =10:1) and recrystallized from chloroform-ethyl acetate to provide the title compound as colorless solid (217 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05753664 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-3ddc57861c1844419b8c3addf562f6f4 |
| Source note | uspto-grants-1998_05 |