Potassium Carbonate → 6-Ethyl-7-methyl-1-[4-[4-(4-picolyloxy)benzoyl]-benzyl]imidazo[1,2-a]pyrimidin-5(1H)-one hydrochloride

Participants

Reaction Steps

A solution of 6-ethyl-1-[4-(4-hydroxybenzoyl)-benzyl]-7-methylimidazo[1,2-a]pyrimidin-5(1H)-one (126 mg), 4-picolyl chloride hydrochloride (154 mg) and potassium carbonate (274 mg) in DMF (7 ml) was stirred at room temperature for 17 hours. This reaction mixture was concentrated and the residue was dissolved in ethyl acetate. The solution was washed with water, dried, and concentrated. The residue was purified by silica gel column chromatography (chloroform: methanol =19:1) and treated with hydrogen chloride/ethyl acetate to provide the title compound as colorless solid (140 mg).

Provenance & Evidence