Potassium Carbonate → HCID 18918853, compound

Participants

Reaction Steps

A solution of 2-[4-(4-hydroxybenzoyl)benzylthio]-3-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (214 mg), 4-(2-chloroethyl)morpholine hydrochloride (157 mg) and potassium carbonate (247 mg) in DMF (7 ml) was stirred at 80° C. for 4 hours. This reaction mixture was concentrated and the residue was dissolved in ethyl acetate, washed with water, and dried. Then, hydrogen chloride/ethyl acetate was added and the precipitated hydrochloride was recovered by filtration and dried to provide the title compound as colorless solid (182 mg).

Provenance & Evidence