Hydrochloric Acid → HCID 69962309, compound

Participants

Reaction Steps

To a solution of 3-acetoxyethyl-7-[4-(4-chlorobenzoyl)benzyl]-2-methylthio-7H-pyrrolo[2,3-d]pyrimidin-4-one (410 mg) in methanol (8 ml)-DME (4 ml) was added 1N-aqueous sodium hydroxide solution (1.64 ml) and the mixture was stirred for 2 hours. This reaction mixture was neutralized with 1N-hydrochloric acid (1.64 ml) and the precipitate was collected by filtration, washed serially with water, methanol and ether, and dried to provide the title compound (295 mg).

Provenance & Evidence