Acetic Anhydride → HCID 69960504, compound

HRID 1291402Notes

Reaction equation

HRID 1291402 reaction equation
[CH3:1][C:2]1[N:11]([CH3:12])[C:10](=[O:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[CH3:14])[N:3]=1.[F:15][C:16]([F:34])([F:33])[C:17]1[CH:32]=[CH:31][C:20]([C:21]([C:23]2[CH:30]=[CH:29][C:26]([CH:27]=O)=[CH:25][CH:24]=2)=[O:22])=[CH:19][CH:18]=1.C(OC(=O)C)(=O)C>>[CH3:12][N:11]1[C:10](=[O:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[CH3:14])[N:3]=[C:2]1[CH:1]=[CH:27][C:26]1[CH:29]=[CH:30][C:23]([C:21](=[O:22])[C:20]2[CH:31]=[CH:32][C:17]([C:16]([F:15])([F:33])[F:34])=[CH:18][CH:19]=2)=[CH:24][CH:25]=1

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 18919036HCID 18919036, compoundHCID 18919240HCID 18919240, compound

Product 1

HCID 69960504HCID 69960504, compoundYield 74.2%

Conditions

Temperature
140 °C

Procedure

To a mixture of 2,3,5-trimethyl-4(3H)-quinazolinone (508 mg) and 4-(4-trifluoromethylbenzoyl)benzaldehyde (751 mg) was added acetic anhydride (1.0 ml) and the mixture was stirred at 140° C. for 2 hours. This reaction mixture was concentrated and the residue was washed with n-hexane-diethyl ether and dried to provide 898 mg of yellow powder.

Workup

  1. concentrationThis reaction mixture was concentrated
  2. washthe residue was washed with n-hexane-diethyl ether
  3. customdried

Sources & evidence

ORD record
ord-94bb0b9187a143e2ac63c91b53b18b27
Source dataset
uspto-grants-1998_05
Patent number
US05753664

Reaction notes

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