Acetic Anhydride → HCID 69960253, compound

HRID 1291404Notes

Reaction equation

HRID 1291404 reaction equation
[CH3:1][C:2]1[N:11]([CH3:12])[C:10](=[O:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[CH3:14])[N:3]=1.[C:15]([O:18][C:19]1[CH:34]=[CH:33][C:22]([C:23]([C:25]2[CH:32]=[CH:31][C:28]([CH:29]=O)=[CH:27][CH:26]=2)=[O:24])=[CH:21][CH:20]=1)(=[O:17])[CH3:16].C(OC(=O)C)(=O)C>>[C:15]([O:18][C:19]1[CH:34]=[CH:33][C:22]([C:23]([C:25]2[CH:26]=[CH:27][C:28]([CH:29]=[CH:1][C:2]3[N:11]([CH3:12])[C:10](=[O:13])[C:9]4[C:4](=[CH:5][CH:6]=[CH:7][C:8]=4[CH3:14])[N:3]=3)=[CH:31][CH:32]=2)=[O:24])=[CH:21][CH:20]=1)(=[O:17])[CH3:16]

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 18919006HCID 18919006, compoundHCID 18919240HCID 18919240, compound

Product 1

HCID 69960253HCID 69960253, compoundYield 74.6%

Conditions

Temperature
140 °C

Procedure

To a mixture of 2,3,5-trimethyl-4(3H)-quinazolinone (376 mg) and 4-(4-acetoxybenzoyl)benzaldehyde (537 mg) was added acetic anhydride (0.5 ml) and the mixture was stirred at 140° C for 2 hours. This reaction mixture was concentrated and the residue was washed with n-hexane-diethyl ether and dried to provide 653 mg of yellow powder.

Workup

  1. concentrationThis reaction mixture was concentrated
  2. washthe residue was washed with n-hexane-diethyl ether
  3. customdried

Sources & evidence

ORD record
ord-0f4bcf9717b64049a3b09c192bd84a16
Source dataset
uspto-grants-1998_05
Patent number
US05753664

Reaction notes

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