Acetic Anhydride → HCID 73470985, compound

HRID 1291407Notes

Reaction equation

HRID 1291407 reaction equation
[CH3:1][C:2]1[N:11]([CH3:12])[C:10](=[O:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[CH3:14])[N:3]=1.[Cl:15][C:16]1[CH:31]=[CH:30][C:19]([C:20]([C:22]2[CH:29]=[CH:28][C:25]([CH:26]=O)=[CH:24][CH:23]=2)=[O:21])=[CH:18][N:17]=1.C(OC(=O)C)(=O)C>>[Cl:15][C:16]1[CH:31]=[CH:30][C:19]([C:20]([C:22]2[CH:29]=[CH:28][C:25]([CH:26]=[CH:1][C:2]3[N:11]([CH3:12])[C:10](=[O:13])[C:9]4[C:4](=[CH:5][CH:6]=[CH:7][C:8]=4[CH3:14])[N:3]=3)=[CH:24][CH:23]=2)=[O:21])=[CH:18][N:17]=1

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 18918805HCID 18918805, compoundHCID 18919240HCID 18919240, compound

Product 1

HCID 73470985HCID 73470985, compoundYield 57.6%

Conditions

Temperature
140 °C

Procedure

To a mixture of 2,3,5-trimethyl-4(3H)-quinazolinone (1.1 g) and 4-(6-chloronicotinoyl)benzaldehyde (1.5 g) was added acetic anhydride (2 ml) and the mixture was stirred at 140° C for 2 hours. This reaction mixture was concentrated and the residue was washed with toluene-diethyl ether and dried to provide 1.4 g of yellow powder.

Workup

  1. concentrationThis reaction mixture was concentrated
  2. washthe residue was washed with toluene-diethyl ether
  3. customdried

Sources & evidence

ORD record
ord-74dccca907f64fafbd7eb4e4efecbc64
Source dataset
uspto-grants-1998_05
Patent number
US05753664

Reaction notes

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