Potassium Carbonate → HCID 18919031, compound

Participants

Reaction Steps

A solution of 3-methylxanthine (204 mg), potassium carbonate (340 mg) and 4-(4-chlorobenzoyl)benzyl bromide (754 mg) in DMF (10 ml) was stirred at 60° C. for 5 hours. This reaction mixture was poured in water and extracted with ethyl acetate. The extract was washed with water, dried, and concentrated. The residue was purified by silica gel column chromatography (hexane: ethyl acetate =1:1) and recrystallized from ethyl acetate-hexane to provide the title compound as colorless solid (184 mg).

Provenance & Evidence