Potassium Carbonate → HCID 18919194, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3,6-dimethyl-2-hydroxy-5H-thiazolo[3,2-a]pyrimidin-5-one (513 mg) and potassium carbonate (741 mg) in DMF (10 ml) was added 4-(4-fluorobenzoyl)benzyl bromide (782 mg) and the mixture was stirred at 80° C. for 2 hours. This reaction mixture was concentrated and the residue was diluted with water-ethyl acetate and extracted with ethyl acetate. The extract was purified by silica gel column chromatography (hexane: ethyl acetate =2:1) and recrystallized from ethyl acetate to provide the title compound as colorless solid (76 mg).

Provenance & Evidence