Carbon tetrabromide → HCID 18919330, compound

Participants

Reaction Steps

In dichloromethane (25 ml) was dissolved 2-[4-(4-hydroxymethylpiperidylcarbonyl)benzylthio]-3,5-dimethyl-4(3H)-quinazolinone (1.081 g) followed by addition of carbon tetrabromide (1.050 g). Then, triphenylphosphine (982 mg) was added over 10 minutes and the mixture was stirred at room temperature for 2 hours. The salt was filtered off and the filtrate was concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate =1:1) and rinsed with ether to provide the title compound as colorless solid (496 mg).

Provenance & Evidence