HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol → 1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-(4-trifluoromethoxyphenyl)-5(1H,4H)-tetrazolone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol | HCID 10631861 | — |
| Reactant | HCID 135507047 | HCID 135507047 | — |
| Product | 1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-(4-trifluoromethoxyphenyl)-5(1H,4H)-tetrazolone | HCID 10693799 | 66.5% |
Reaction Steps
In the same manner as in Reference Example 5, starting from 1.54 g of (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol and 1.52 g of 1-(4-trifluoromethoxyphenyl)-5(1H,4H)-tetrazolone, 1.76 g of 1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-(4-trifluoromethoxyphenyl)-5(1H,4H)-tetrazolone was obtained as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05466820 |
| Source dataset | uspto-grants-1995_11 |
| ORD ID | ord-c3e29d24def841cfa894e3a9ed0a91e1 |
| Source note | uspto-grants-1995_11 |