Water → HCID 18919308, compound

Participants

Reaction Steps

In THF (76.8 ml) was dissolved 7-[4-(4-t-butyldimethylsilyloxybenzoyl)benzyl]-3-ethyl-2-methylthio-7H-pyrrolo[2,3-d]pyrimidin-4-one (4.10 g) followed by addition of 1M-tetrabutylammonium fluoride-THF (7.68 ml), and the mixture was stirred for 30 minutes. To this reaction mixture was added water and the THF was distilled off. Then, ethyl acetate was added to the residue and the organic layer was separated. The organic layer was washed with saturated aqueous NaCl solution and dried over anhydrous sodium sulfate and the solvent was then distilled off under reduced pressure. The residue was triturated with ether and the resulting powder was collected by filtration, rinsed with ether, methanol and hexane, and dried to provide the title compound as crystalline powder (3.0 g)

Provenance & Evidence