Potassium Carbonate → HCID 18918873, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 7-hydroxy-6-methyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-one (1.0 g) and potassium carbonate (750 mg) in DMF (15 ml) was added 4-(4-chlorobenzoyl)benzyl bromide (2.0 g) and the mixture was stirred at 60° C. for 2 hours. This reaction mixture was concentrated and the residue was purified by silica gel column chromatography (hexane-ethyl acetate =1:1) and recrystallized from isopropyl ether to provide the title compound as colorless solid (200 mg).

Provenance & Evidence