Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol → 4-(4-chlorophenyl)-2-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-3(2H,4H)-1,2,4-triazolone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol | HCID 10631861 | — |
| 반응물 | 4-(4-Chlorophenyl)-1H-1,2,4-triazol-5(4H)-one | HCID 19689796 | — |
| 생성물 | 4-(4-chlorophenyl)-2-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-3(2H,4H)-1,2,4-triazolone | HCID 11595984 | 18.5% |
반응 단계
In the same manner as in Reference Example 5, starting from 0.66 g of (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol and 0.65 g of 4-(4-chlorophenyl)-3(2H,4H)-1,2,4-triazolone, 0.23 g of 4-(4-chlorophenyl)-2-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-3(2H,4H)-1,2,4-triazolone was obtained as a colorless viscous oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05466820 |
| 출처 데이터셋 | uspto-grants-1995_11 |
| ORD ID | ord-527d3715e2814a0aa4b36f4417eff0cb |
| 출처 메모 | uspto-grants-1995_11 |