Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-Pyridin-3-yl-1,2,5-oxadiazol-3-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Phosphorus pentachloride | HCID 24819 | — |
| 반응물 | alpha-Oximino-3-pyridylacetamidoxime | HCID 136341185 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 4-Pyridin-3-yl-1,2,5-oxadiazol-3-amine | HCID 1415523 | — |
반응 단계
Crude alpha-oximino-3-pyridylacetamidoxime (5 g) and phosphorus pentachloride (5 g) was refluxed in dry ether (250 ml) for 6 h. Water and potassium carbonate to alkaline pH was added and the phases separated. The aqueous phase was extracted with ether and the combined ether phases dried. Evaporation of the ether phases gave the title compound in 850 mg yield; M+ : 162.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05753683 |
| 출처 데이터셋 | uspto-grants-1998_05 |
| ORD ID | ord-43bc2b65a7c94b2e9f1d8a6667dce76c |
| 출처 메모 | uspto-grants-1998_05 |