Methyl iodide → 3-(3-Amino-1,2,5-oxadiazol-4-yl)-1-methylpyridinium iodide

HRID 1291514Notes

Reaction equation

HRID 1291514 reaction equation
[NH2:1][C:2]1[C:6]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)=[N:5][O:4][N:3]=1.[CH3:13][I:14]>CC(C)=O>[I-:14].[NH2:1][C:2]1[C:6]([C:7]2[CH:8]=[N+:9]([CH3:13])[CH:10]=[CH:11][CH:12]=2)=[N:5][O:4][N:3]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 14155234-Pyridin-3-yl-1,2,5-oxadiazol-3-amine

Product 1

HCID 190753223-(3-Amino-1,2,5-oxadiazol-4-yl)-1-methylpyridinium iodide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of 3-(3-amino-1,2,5-oxadiazol-4-yl)pyridine (870 mg, 5.3 mmol) in acetone (20 ml) was added methyl iodide (990 μl, 16 mmol) and the reaction mixture was stirred overnight at room temperature. The title compound precipitated and was collected by filtration (1.1 g, 69%).

Workup

  1. customThe title compound precipitated
  2. filtrationwas collected by filtration (1.1 g, 69%)

Sources & evidence

ORD record
ord-9e54e2f392f047dd9f0dcfc1b9c86741
Source dataset
uspto-grants-1998_05
Patent number
US05753683

Reaction notes

Loading…