[2,2'-Bithiophene]-5-carboxaldehyde → HCID 86750361, compound

HRID 1291584Notes

Reaction equation

HRID 1291584 reaction equation
[CH:1]([C:3]1[S:7][C:6]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)=[CH:5][CH:4]=1)=O.[OH:13][C:14]([CH2:17][OH:18])=[CH:15][NH2:16]>C1C=CC=CC=1>[OH:13][CH:14]([CH2:17][OH:18])[CH2:15][N:16]=[C:1]=[C:3]1[S:7][C:6]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)=[CH:5][CH2:4]1

Participants

4

Reactant 2

HCID 364428[2,2'-Bithiophene]-5-carboxaldehydeHCID 73471098HCID 73471098, compound

Product 1

HCID 86750361HCID 86750361, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Conditions

Temperature
85 °C

Procedure

5.74 g of 5-formyl-2,2'-bithiophene was dissolved in 60 ml of benzene, followed by dropping in excess 2,3-dihydroxy-propenylamine and refluxed at 85° C. for 5 hours with molecular sieves. Then the benzene was evaporated under reduced pressure and 9.68 g of residual solid was obtained. A yellowish product (85%) could be further recrystallized from ethanol.

Workup

  1. customThen the benzene was evaporated under reduced pressure

Sources & evidence

ORD record
ord-db90a81245274e41b2f4f371b58b4db1
Source dataset
uspto-grants-1998_05
Patent number
US05753692

Reaction notes

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