Potassium Hydroxide → HCID 54538891, compound

HRID 1291587Notes

Reaction equation

HRID 1291587 reaction equation
[CH:1]([C:3]1[S:7][C:6]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)=[CH:5][CH:4]=1)=O.[OH:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][C:21](CC2C=CC(O)=CC=2)=O)=[CH:16][CH:15]=1.[OH-:31].[K+]>C(O)C>[OH:13][C:14]1[CH:19]=[CH:18][C:17]([C:20](=[O:31])[CH:21]=[CH:1][C:3]2[S:7][C:6]([C:8]3[S:9][CH:10]=[CH:11][CH:12]=3)=[CH:5][CH:4]=2)=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 364428[2,2'-Bithiophene]-5-carboxaldehydeHCID 641303HCID 641303, compound

Product 1

HCID 54538891HCID 54538891, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.94 g of 5-formyl-2,2'-bithiophene was dissolved in 15 ml of ethanol. Then 1.36 g of p-hydroxyphenyl-methyl-ketone was added in, followed by adding KOH (1 g dissolved in H2O and ethanol), the color of the mixture turned into orange. Some crude crystals were crystallized and dissolved later. The reaction solution was placed in a refrigerator overnight. The next day, it was decomposed with ice water and 2 ml of acetic acid were added. The crude product was collected and recrystallized from ethanol, 0.52 g of golden crystal product was thus obtained and the melting point thereof was 202°-205° C.

Workup

  1. customSome crude crystals were crystallized
  2. dissolutiondissolved later
  3. customwas placed in a refrigerator overnight
  4. additionwere added
  5. customThe crude product was collected
  6. customrecrystallized from ethanol, 0.52 g of golden crystal product
  7. customwas thus obtained
  8. customthereof was 202°-205° C.

Sources & evidence

ORD record
ord-2bc8d09cc49644cea63c8400a71708b4
Source dataset
uspto-grants-1998_05
Patent number
US05753692

Reaction notes

Loading…