Sodium hydride → HCID 15860308, compound

Participants

Reaction Steps

(trans)-3-(2-Fluoro-5-methoxyphenyl)-2-propenenitrile: To a suspension of NaH (6.90 g, 60% dispersion in mineral oil, 173 mmol) in THF (500 mL) at 0° C. was added diethyl cyanomethylphosphonate (30.10 g, 170 mmol) dropwise. This was followed by the dropwise addition of a solution of 2-fluoro-5-methoxybenzaldehyde (24.5 g, 159 mmol) in THF (50 mL). The resulting suspension was allowed to warm to ambient temperature. After 18 h, H2O (200 mL) was added and the solution was extracted with EtOAc. The organics were combined, washed with brine, dried over MgSO4, and concentrated to afford a white waxy solid. The material was then purified by Kugelrohr distillation to give the title compound, 24.3 g (86%): mp 56°-57° C.;

Provenance & Evidence