(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol → HCID 10790126, compound

HRID 129171Notes

Reaction equation

HRID 129171 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@@H:12](O)[CH3:13])[CH2:11][O:10]1.[F:15][C:16]([F:33])([O:20][C:21]1[CH:26]=[CH:25][C:24]([N:27]2[C:31](=[O:32])[NH:30][N:29]=[N:28]2)=[CH:23][CH:22]=1)[CH:17]([F:19])[F:18]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([O:10][CH2:11]1)[C@H:12]([N:30]1[C:31](=[O:32])[N:27]([C:24]2[CH:23]=[CH:22][C:21]([O:20][C:16]([F:15])([F:33])[CH:17]([F:19])[F:18])=[CH:26][CH:25]=2)[N:28]=[N:29]1)[CH3:13]

Participants

3

Reactant 2

HCID 10631861(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanolHCID 135513824HCID 135513824, compound

Product 1

HCID 10790126HCID 10790126, compoundYield 66.1%

Procedure

In the same manner as in Reference Example 5, starting from 1.049 g of (1S)-1-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol and 1.17 g of 1-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]- 5(1H,4H)-tetrazolone, 1.28 g of 1-[(1R, 2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl ]-4-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]-5(1H,4H)-tetrazolone was obtained as a colorless oil.

Sources & evidence

ORD record
ord-19dfb61c254e40f0aa2d11bf2d5b3a47
Source dataset
uspto-grants-1995_11
Patent number
US05466820

Reaction notes

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