Butyl iodide → HCID 23302093, compound

Participants

Reaction Steps

Combine 3.5 gm (0.0053 mol) of the product of Step C of Example 1, 2.7 gm (0.024 mol) of KtBuO, 2.57 ml (0.024 mol) of 1-iodobutane in 10 ml of DMF and allow the mixture to stir for 18 hours. Evaporate the volatiles (0.5 mm at 45° C.), dissolve the residue in 500 ml of EtOAc, water-wash (2× with 100 ml) the organic layer and dry the organic layer over MgSO4. Evaporate off the solvents and subject the residue to flash chromatography (silica gel eluted with 20% EtOAc/hexane to yield 1.32 gm of the title compound. Rf is 0.36 (silica gel plates eluted with 20% EtOAc/hexane).

Provenance & Evidence