HCID 18920516, compound → HCID 18920512, compound

HRID 1291727Notes

Reaction equation

HRID 1291727 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6](CC1C=CC=CC=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15](CC1C=CC=CC=1)[CH2:16][CH2:17][CH2:18][CH2:19][OH:20].[H][H]>[Pd]=O.CC(O)=O>[OH:20][CH2:19][CH2:18][CH2:17][CH2:16][NH:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][NH:6][CH2:5][CH2:4][CH2:3][CH2:2][OH:1]

Participants

5

Reactant 2

HCID 18920516HCID 18920516, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18920512HCID 18920512, compound

Reagents, catalysts & solvents 2

HCID 5083724Palladium monoxideCatalystHCID 176Acetic AcidSolvent

Procedure

Hydrogenate a mixture containing 3.0 gm of the product of Step D, 30 ml of AcOH and 0.6 gm of palladium oxide at 45 lbs./sq.in. until no further hydrogen is taken up. Filter and remove the solvent (in vacuo) to yield 1.77 gm of the desired product, Rf is 0.37 (eluted from silica gel with 10% conc. NH3 /CH3OH).

Workup

  1. filtrationFilter
  2. customremove the solvent (in vacuo)
  3. customto yield
  4. wash1.77 gm of the desired product, Rf is 0.37 (eluted from silica gel with 10% conc. NH3 /CH3OH)

Sources & evidence

ORD record
ord-55ca104ef1ce4890ae390c661879b06a
Source dataset
uspto-grants-1998_05
Patent number
US05753714

Reaction notes

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