(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol → HCID 18657644, compound

HRID 129175Notes

Reaction equation

HRID 129175 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@@H:12](O)[CH3:13])[CH2:11][O:10]1.[CH3:15][C:16]1[NH:17][C:18](=[O:32])[N:19]([C:21]2[CH:26]=[CH:25][C:24]([O:27][C:28]([F:31])([F:30])[F:29])=[CH:23][CH:22]=2)[N:20]=1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([O:10][CH2:11]1)[C@H:12]([N:17]1[C:16]([CH3:15])=[N:20][N:19]([C:21]2[CH:26]=[CH:25][C:24]([O:27][C:28]([F:30])([F:31])[F:29])=[CH:23][CH:22]=2)[C:18]1=[O:32])[CH3:13]

Participants

3

Reactant 2

HCID 10631861(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanolHCID 135991660155432-20-5

Product 1

HCID 18657644HCID 18657644, compoundYield 14.7%

Procedure

In the same manner as in Reference Example 5, starting from 0.50 g of (1S)-1-[(2R)-(2,4-difluorophenyl)-2-oxiranyl] ethanol and 0.52 g of 5-methyl-2-(4-trifluoromethoxyphenyl)-3(2H,4H)-1,2,4-triazolone, 0.13 g of 4-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-5-methyl-2-(4-trifluoromethoxyphenyl)-3(2H,4H)-1,2,4-triazolone was obtained as a colorless viscous oil.

Sources & evidence

ORD record
ord-ed86db96d407446cb977ab162d623654
Source dataset
uspto-grants-1995_11
Patent number
US05466820

Reaction notes

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