Potassium Carbonate → HCID 10763050, compound

Participants

Reaction Conditions

Reaction Steps

Under a nitrogen atmosphere, 326 mg (0.669 mmol) of 1-[2(R)-hydroxy-3(S)-(trifluoroacetylamino)-4-phenyl-butyl]-1-[cyclohexylmethyl]-2-[tert-butoxycarbonyl]-hydrazine dissolved in 52 ml of MeOH are heated to 70° C., 17 ml of 1M aqueous K2CO3 solution are added dropwise and the mixture is stirred for 16 h at 70° C. The reaction mixture is concentrated by evaporation and the residue is partitioned between 3 portions of methylene chloride, 2 portions of water and brine. Concentration by evaporation of the organic phases which have been dried with Na2SO4 yields the title compound, which is used directly in the next step: 1H-NMR (200 MHz, CD3OD): 1.42 (s, 9 H, Boc), 0.8-2.1 (m, 11 H, cyclohexyl), 2.4-3.0 (m, 6H), 3.1 (m, 1H), 3.54 (m, 1H), 7.28 (m, 5H).

Provenance & Evidence