Potassium Hydroxide → HCID 18918333, compound

Participants

Reaction Steps

A mixture of the product of step (iv) (1.8 g), ethanol (40 ml) and 20% w/v aqueous potassium hydroxide solution (40 ml) was heated to reflux overnight, cooled and evaporated to dryness. The residue was partitioned between water and dichloromethane and the organic layer was separated, washed with brine, dried (MgSO4) and evaporated to yield 1-benzyl-3-(piperazin-1-yl)-7-methoxy-4-quinolone (1.5 g) as a yellow foam: NMR (CDCl3) δ 2.80 (1H, m), 3.20 (8H, m), 3.73 (3H, s), 5.28 (2H, s), 6.59 (1H, d), 6.88 (1H, dd), 7.15 (3H, m), 7.30 (3H, m), 8.41 (1H, d); m/Z 350 (N+H)+.

Provenance & Evidence