Pyridine → HCID 18913754, compound

HRID 1291956Notes

Reaction equation

HRID 1291956 reaction equation
[CH2:1]([O:6][CH2:7][C:8]1[CH:26]=[CH:25][C:11]([C:12](OC2C=C(F)C(C#N)=C(F)C=2)=[O:13])=[CH:10][CH:9]=1)[CH2:2][CH2:3][CH2:4][CH3:5].C(OCC1C=CC(C(O)=O)=CC=1)CCCC.S(Cl)([Cl:45])=O.N1C=CC=CC=1>C1(C)C=CC=CC=1>[CH2:1]([O:6][CH2:7][C:8]1[CH:26]=[CH:25][C:11]([C:12]([Cl:45])=[O:13])=[CH:10][CH:9]=1)[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

6

Reactant 4

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 18913736HCID 18913736, compoundHCID 541458803,5-Difluoro-4-cyanophenyl 4-(pentyloxymethyl)benzoate

Product 1

HCID 18913754HCID 18913754, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Preparation of 3,5-difluoro-4-cyanophenyl 4-(pentyloxymethyl)benzoate (in the formula (1), R=C5H11, l=1, m=1, n and o=both, 0; A1 =1,4- phenylene group, Z1 =--COO--, X=CN, and Y1 and Y2 =both, F) (Compound No. 1)) 4-(Pentyloxymethyl)benzoic acid. (1.6 g, 7.1 mmol) was mixed with thionyl chloride (1.3 g, 10.6 mmol), pyridine (0.1 ml) and toluene (3 ml), followed by reacting them at 80° C. for 2 hours, and distilling off superfluous thionyl chloride and toluene under reduced pressure, to obtain raw 4-(pentyloxymethyl)benzoyl chloride.

Workup

  1. customat 80° C.
  2. customfor 2 hours
  3. distillationdistilling off superfluous thionyl chloride and toluene under reduced pressure

Sources & evidence

ORD record
ord-c04a6a268c2c43eb8c048316f482dafd
Source dataset
uspto-grants-1998_05
Patent number
US05755994

Reaction notes

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