Thionyl Chloride → 4-(Butoxymethyl)benzoyl chloride

Participants

Reaction Steps

Preparation of trans-4-(3,5-difluoro-4-cyanophenyl)-cyclohexyl 4-(butoxymethyl)benzoate (in the formula (1), R=C4H9, l=1, m and n=both, 1, o=0, A1 =1,4-phenylene group, A2 =trans-1,4-cyclohexylene group, Z1 =--COO--, Z2 =covalent bond, X=CN, and Y1 and Y2 =both, F) (Compound No. 148) 4-(butoxymethyl)benzoic acid (1.5 g, 7.2 mmol) was mixed with thionyl chloride (1.3 g, 10.8 mmol) pyridine (0.1 ml) and toluene (3 ml), followed by reacting them at 80° C., for 2 hours, and distilling off superfluous thionyl chloride and toluene under reduced pressure, to obtain raw 4-(butoxymethyl)benzoyl chloride.

Provenance & Evidence