反应详情

0.28 g (1 mmol) 4-Acetyl-5-amino-1-(3-chloro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-2-yl)pyrazole was dissolved in 5 ml dimethoxyethane and treated with 0.28 (0.6 mmol) Lawesson's reagent. After heating under reflux for 2 hours with stirring, the reaction solution was poured into water and extracted with ethyl acetate. The organic phase was washed with saturated aqueous sodium chloride, dried over magnesium sulfate and concentrated. The residue was purified by silica gel column chromatography. (Hexane/ethyl acetate 1:1).

1. temperatureAfter heating
2. temperatureunder reflux for 2 hours
3. extractionextracted with ethyl acetate
4. washThe organic phase was washed with saturated aqueous sodium chloride
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated
7. customThe residue was purified by silica gel column chromatography